Home › Openings › Sicilian Defense › Sicilian Defense: Four Knights Variation Sicilian Defense: Four Knights Variation, Exchange Variation ECO B45 · 1. e4 c5 2. Nf3 e6 3. d4 cxd4 4. Nxd4 Nc6 5. Nc3 Nf6 6. Nxc6 Related variationsSicilian Defense: Four Knights Variation, Cobra VariationSicilian Defense: Four Knights Variation, Sveshnikov TransferSicilian Defense: Four Knights Variation, American Attack Practice this opening · Play against the computer